Defending champion Rafael Nadal could meet world no 1 Novak Djokovic in the French Open semi-finals after the pair landed in the same half of the men’s draw.
The 34-year-old Spaniard is a record 13-time champion at Roland Garros but is seeded third behind Djokovic and Daniil Medvedev.
Swiss eighth seed Roger Federer has also been drawn in the same half as Nadal and Djokovic.
Federer, 39, returns to the Paris clay after missing last year’s tournament through injury and will face a qualifier in his opening match, with Djokovic potentially looming in the quarter-finals.
Nadal opens against Australia’s Alexei Popyrin, while Serbia’s Djokovic plays American Tennys Sandgren.
In the women’s draw for the tournament that starts on Sunday, Australian world number one Ashleigh Barty starts against 70th-ranked American Bernarda Pera.
Japanese second seed Naomi Osaka, who says she will not speak to the media during the tournament, faces Romania’s Patricia Maria Tig.
Polish teenager Iga Swiatek opens her defence of the title against her close friend Kaja Juvan of Slovenia, while last year’s runner-up Sofia Kenin faces 2017 champion Jelena Ostapenko.
Serena Williams, bidding for a record-equalling 24th Grand Slam singles title, starts against Romania’s world number 74 Irina-Camelia Begu.